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Dr Gursimran ChandhokSimran completed her Masters in Medical Biotechnology at the School of Life Sciences, Manipal University, India in 2010. She worked on the screening of gene mutations in leukemia and myeloid disorders, and evaluation of potential surrogate markers in head and neck cancer during her undergraduate and postgraduate studies. In 2011, she received the FP7- Marie Curie Actions, People - IRSES grant to pursue her doctoral studies in Germany. She completed her Ph.D. in Molecular and Cell Biology at University of Muenster, Germany in 2015 under the supervision of Prof. Hartmut H.J. Schmidt. Her PhD project primarily focused on the functional analysis and characterization of different copper transporter ATP7B mutants. During her doctoral studies, she generated a stable human ATP7B knockout hepatic cell line using Zinc finger nucleases and characterized it as a cell model to study Wilson disease (WD). She then used this cell line to study the molecular underpinnings of WD and to explain how the WD gene mutation results in a specific phenotype. Furthermore, she also evaluated the efficacy of various therapies, including currently available and novel drugs in different ATP7B mutants. Currently, she is interested in identifying novel genetic modulators of Mitofusin 2 ortholog in C. elegans, and characterizing their function to uncover novel information into the role of mitochondria in neuronal health and disease.
Simran joined the Neumann lab in February 2017. |
Publications
Dhananjay S, Chandhok G*, Neumann B* (2022). Novel putative interactors of FZO-1/mitofusin 2 identified using large-scale yeast two-hybrid screening in C. elegans. Micropublication: biology. 10.17912/micropub.biology.000674. Journal link.
Teoh JS, Vasudevan A, Wang W, Dhananjay S, Chandhok G, Pocock R, Koushika SP, Neumann B (2022). Synaptic branch stability is mediated by non‑enzymatic functions of MEC‑17/αTAT1 and ATAT‑2. Scientific Reports 12, 14003. https://doi.org/10.1038/s41598-022-18333-2. Journal link.
Byrne JJ, Soh MS*, Chandhok G*, Vijayaraghavan T, Teoh JS, Crawford S, Cobham AE, Yapa NMB, Mirth CK, Neumann B (2019). Disruption of mitochondrial dynamics affects behaviour and lifespan in Caenorhabditis elegans. Cellular and Molecular Life Sciences https://doi.org/10.1007/s00018-019-03024-5. Brief summary.
Kara D, Hüsing-Kabar A, Schmidt H, Grünewald I, Chandhok G, Maschmeier M, and Kabar I (2018). Portal Hypertensive Polyposis in Advanced Liver Cirrhosis: The Unknown Entity? Canadian Journal of Gastroenterology and Hepatology. Article ID 2182784; https://doi.org/10.1155/2018/2182784. Journal link.
Guttmann S*, Chandhok G*, Groba SR, Niemietz C, Sauer V, Gomes A, Ciarimboli G, Karst U, Zibert A, Schmidt HH (2018). Organic cation transporter 3 mediates cisplatin and copper cross-resistance in hepatoma cells. Oncotarget. 9: 743-754. *Equal contribution. Journal link.
Chandhok S, Lazarou M, and Neumann B (2018). Structure, Function, and Regulation of Mitofusin-2 in Health and Disease. Biological Reviews - Review 93(2): 933-949. Journal link.
Niemietz C, Chandhok G, Fleischhauer L, Ballmaier P, Sauer V, Guttmann S, Zibert A, Schmidt H (2017). FAP plasma-induced cellular toxicity. Amyloid. Mar;24(sup1): 87-88. doi: 10.1080/13506129.2017. PubMed Link.
Verbandt S, Henriques ST, Spincemaille P, Harvey PJ, Chandhok G, Sauer V, De Coninck B, Cassiman D, Craik DJ, Cammue BP, De Cremer K, Thevissen K (2017). Identification of survival-promoting OSIP108 peptide variants and their internalization in human cells. Mechanisms of Ageing and Development, 161(Pt B): 247-254. PubMed link.
Niemietz CJ, Sauer V, Stella J, Fleischhauer L, Chandhok G, Guttmann S, Avsar Y, Guo S, Ackermann EJ, Gollob J, Monia BP, Zibert A, Schmidt HH (2016). Evaluation of Therapeutic Oligonucleotides for Familial Amyloid Polyneuropathy in Patient-Derived Hepatocyte-Like Cells. PLoS One. 1;11(9):e0161455. PubMed Link.
Chandhok G*, Soh MS* (2016). Presynaptic deficits at neuromuscular junctions: a specific cause and potential target of axonal neuropathy in type 2 Charcot-Marie-Tooth disease. The Journal of Neuroscience - Review, 3;36(31): 8067-9. *Equal contribution. PubMed link.
Chandhok G, Horvath J, Aggarwal A, Bhatt M, Zibert A, Schmidt HH (2016). Functional analysis and drug response to zinc and D-penicillamine in stable ATP7B mutant hepatic cell lines. World J Gastroenterol, 28;22(16): 4109-19. PubMed link.
Niemietz C*, Chandhok G*, Schmidt H (2015). Therapeutic Oligonucleotides Targeting Liver Disease: TTR Amyloidosis. Molecules, 30;20(10): 17944-75. *Equal contribution. PubMed link.
Spincemaille P, Pham DH, Chandhok G, Verbeek J, Zibert A, Libbrecht L, Schmidt H, Esguerra CV, de Witte PA, Cammue BP, Cassiman D, Thevissen K (2014). The plant decapeptide OSIP108 prevents copper-induced toxicity in various models for Wilson disease. Toxicol Appl Pharmacol, 15;280(2): 345-51. PubMed link.
Chandhok G, Schmitt N, Sauer V, Aggarwal A, Bhatt M, Schmidt HH (2014). The effect of zinc and D-penicillamine in a stable human hepatoma ATP7B knockout cell line. PLoS One, 3; 9(6):e98809. PubMed link.
Spincemaille P*, Chandhok G*, Zibert A, Schmidt HH, Verbeek J, Chaltin P, Cammue B, Cassiman D, Thevissen K (2014). Angiotensin II type 1 receptor blockers increase tolerance of cells to copper and cisplatin. Microbial Cell, 1(11): 352-364. *Equal contribution. Journal Link.
Spincemaille P*, Chandhok G*, Newcomb B, Verbeek J, Vriens K, Zibert A, Schmidt H, Hannun YA, van Pelt J, Cassiman D, Cammue BP, Thevissen K (2014). The plant decapeptide OSIP108 prevents copper-induced apoptosis in yeast and human cells. Biochim Biophys Acta, 1843(6):1207-15. *Equal contribution. PubMed link.
Aggarwal A*, Chandhok G*, Todorov T, Parekh S, Tilve S, Zibert A, Bhatt M, Schmidt HH (2013). Wilson disease mutation pattern with genotype-phenotype correlations from Western India: confirmation of p.C271* as a common Indian mutation and identification of 14 novel mutations. Ann Hum Genet, 77(4): 299-307. *Equal contribution. PubMed link.
Kara D, Hüsing-Kabar A, Schmidt H, Grünewald I, Chandhok G, Maschmeier M, and Kabar I (2018). Portal Hypertensive Polyposis in Advanced Liver Cirrhosis: The Unknown Entity? Canadian Journal of Gastroenterology and Hepatology. Article ID 2182784; https://doi.org/10.1155/2018/2182784. Journal link.
Guttmann S*, Chandhok G*, Groba SR, Niemietz C, Sauer V, Gomes A, Ciarimboli G, Karst U, Zibert A, Schmidt HH (2018). Organic cation transporter 3 mediates cisplatin and copper cross-resistance in hepatoma cells. Oncotarget. 9: 743-754. *Equal contribution. Journal link.
Chandhok S, Lazarou M, and Neumann B (2018). Structure, Function, and Regulation of Mitofusin-2 in Health and Disease. Biological Reviews - Review 93(2): 933-949. Journal link.
Niemietz C, Chandhok G, Fleischhauer L, Ballmaier P, Sauer V, Guttmann S, Zibert A, Schmidt H (2017). FAP plasma-induced cellular toxicity. Amyloid. Mar;24(sup1): 87-88. doi: 10.1080/13506129.2017. PubMed Link.
Verbandt S, Henriques ST, Spincemaille P, Harvey PJ, Chandhok G, Sauer V, De Coninck B, Cassiman D, Craik DJ, Cammue BP, De Cremer K, Thevissen K (2017). Identification of survival-promoting OSIP108 peptide variants and their internalization in human cells. Mechanisms of Ageing and Development, 161(Pt B): 247-254. PubMed link.
Niemietz CJ, Sauer V, Stella J, Fleischhauer L, Chandhok G, Guttmann S, Avsar Y, Guo S, Ackermann EJ, Gollob J, Monia BP, Zibert A, Schmidt HH (2016). Evaluation of Therapeutic Oligonucleotides for Familial Amyloid Polyneuropathy in Patient-Derived Hepatocyte-Like Cells. PLoS One. 1;11(9):e0161455. PubMed Link.
Chandhok G*, Soh MS* (2016). Presynaptic deficits at neuromuscular junctions: a specific cause and potential target of axonal neuropathy in type 2 Charcot-Marie-Tooth disease. The Journal of Neuroscience - Review, 3;36(31): 8067-9. *Equal contribution. PubMed link.
Chandhok G, Horvath J, Aggarwal A, Bhatt M, Zibert A, Schmidt HH (2016). Functional analysis and drug response to zinc and D-penicillamine in stable ATP7B mutant hepatic cell lines. World J Gastroenterol, 28;22(16): 4109-19. PubMed link.
Niemietz C*, Chandhok G*, Schmidt H (2015). Therapeutic Oligonucleotides Targeting Liver Disease: TTR Amyloidosis. Molecules, 30;20(10): 17944-75. *Equal contribution. PubMed link.
Spincemaille P, Pham DH, Chandhok G, Verbeek J, Zibert A, Libbrecht L, Schmidt H, Esguerra CV, de Witte PA, Cammue BP, Cassiman D, Thevissen K (2014). The plant decapeptide OSIP108 prevents copper-induced toxicity in various models for Wilson disease. Toxicol Appl Pharmacol, 15;280(2): 345-51. PubMed link.
Chandhok G, Schmitt N, Sauer V, Aggarwal A, Bhatt M, Schmidt HH (2014). The effect of zinc and D-penicillamine in a stable human hepatoma ATP7B knockout cell line. PLoS One, 3; 9(6):e98809. PubMed link.
Spincemaille P*, Chandhok G*, Zibert A, Schmidt HH, Verbeek J, Chaltin P, Cammue B, Cassiman D, Thevissen K (2014). Angiotensin II type 1 receptor blockers increase tolerance of cells to copper and cisplatin. Microbial Cell, 1(11): 352-364. *Equal contribution. Journal Link.
Spincemaille P*, Chandhok G*, Newcomb B, Verbeek J, Vriens K, Zibert A, Schmidt H, Hannun YA, van Pelt J, Cassiman D, Cammue BP, Thevissen K (2014). The plant decapeptide OSIP108 prevents copper-induced apoptosis in yeast and human cells. Biochim Biophys Acta, 1843(6):1207-15. *Equal contribution. PubMed link.
Aggarwal A*, Chandhok G*, Todorov T, Parekh S, Tilve S, Zibert A, Bhatt M, Schmidt HH (2013). Wilson disease mutation pattern with genotype-phenotype correlations from Western India: confirmation of p.C271* as a common Indian mutation and identification of 14 novel mutations. Ann Hum Genet, 77(4): 299-307. *Equal contribution. PubMed link.